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We propose a reference architecture of safety-critical or industry-critical human cyber-physical systems (CPSs) capable of expressing essential classes of system-level interactions between CPS and humans relevant for the societal acceptance of such systems. To reach this quality gate, the expressivity of the model must go beyond classical viewpoints such as operational, functional, and architectural views and views used for safety and security analysis. The model does so by incorporating elements of such systems for mutual introspections in situational awareness, capabilities, and intentions to enable a synergetic, trusted relation in the interaction of humans and CPSs, which we see as a prerequisite for their societal acceptance. The reference architecture is represented as a metamodel incorporating conceptual and behavioral semantic aspects. We illustrate the key concepts of the metamodel with examples from cooperative autonomous driving, the operating room of the future, cockpit-tower interaction, and crisis management.